Peripheral blood is another source of obtaining stem cells from the donor. The donor will be given a blood stimulating factor to cause stem cells to migrate from the bone marrow to the peripheral blood. To collect the circulating stem cells, an intravenous line is inserted into the donor's vein and the blood is drawn by a machine where the stem cells are collected while the rest of the blood returns to the donor.
Peripheral blood stem cell donation is a less invasive and painless method of harvesting stem cells as compared to harvesting via the bones themselves. This method is similar to donating blood or platelets.