Bone Marrow and Peripheral Blood Transplantation
Bone marrow has been the trusted treatment for years saving thousands of lives. However, there are limitations and disadvantages of using bone marrow.
Bone marrow donation might seem like a simple process of extracting stem cells from the pelvis area where the bone marrow is found. However, it is a very long process where the donor will have to be called back for a second medical check-up and the Human Leukocyte Antigen (HLA) confirmatory test and donors might back off when being called due to many reasons unforeseen.
Peripheral blood is an easier and more painless method of withdrawing stem cells as compared to bone marrow donation. However, like bone marrow, there are also limitations of using peripheral blood. As the stem cells from peripheral blood are generated from the bone marrow itself, the donor and recipient have to be a perfect match. There is often difficulty finding a perfect match thus, limiting the chances of survival for patients seeking a life-saving stem cell unit.
Graft versus Host Disease is also another pressing issue. Graft refers to the donor's bone marrow and host is the recipient's body system. Our body system, when introduced to a new foreign object, might reject that foreign object and result in further deterioration of the body's immune system.